Thymic selection and autoimmunity
نویسنده
چکیده
APC = antigen presenting cell; cTEC = thymic cortical epithelial cell; DC = dendritic cell; IκB = inhibitory κB; IL = interleukin; mTEC = medullary thymic epithelial cell; NFκB = nuclear factor κB; NIK = NFκB inhibitory kinase; NOD = non-obese diabetic; NZB = New Zealand black; TLR = tolllike receptor; TNF = tumor necrosis factor; TRAF6 = TNF receptor associated factor 6. Arthritis Research & Therapy August 2005 Vol 7 No 4 Thomas
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Autoimmunity-Associated LYP-W620 Does Not Impair Thymic Negative Selection of Autoreactive T Cells
A C1858T (R620W) variation in the PTPN22 gene encoding the tyrosine phosphatase LYP is a major risk factor for human autoimmunity. LYP is a known negative regulator of signaling through the T cell receptor (TCR), and murine Ptpn22 plays a role in thymic selection. However, the mechanism of action of the R620W variant in autoimmunity remains unclear. One model holds that LYP-W620 is a gain-of-fu...
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